Increased Number of Metallo- or OXA Carbapenemase Producing Acinetobacter baumanii Isolated from Tangerang, Indonesia

Background: The escalation of Carbapenem-Resistant Acinetobacter baumanii (CRAB) has created a major issue in the antibiotic option for the patients admitted in intensive care unit globally, including in Indonesia. The aim of our study was to evaluate the presence of metalloor OXA carbapenemase producing A.baumanii and their antibiotic susceptibility level in the clinical specimens.

Methods and Findings: During a 3 year-period, 117 isolates of A.baumanii were collected from patients admitted in the intensive care unit of Siloam General Hospital, Tangerang, Indonesia. All A.baumanii isolates were filtered for antibiotic susceptibility and their phenotypes regarding MICs of ß-lactams class using VITEX-2 AES. Of the entire drugs tested, tigecycline had the highest level of sensitivity. Most of A.baumanii isolates in this study were highly resistant to meropenem and cephalosporins especially ceftriaxone. The prevalence of metallo- or OXA carbapenemase was 55.9% in 2013, 86.8% in 2014, and 62.2% in 2015.

Conclusion: The low number of drug susceptibility among A.baumanii observed in this study demonstrated multidrug-resistant organism especially CRAB, The high level of metallo- or OXA carbapenemase phenotypes was associated with this findings.

Author(s):

Cucunawangsih, Veronica Wiwing, Nicolaski Lumbuun and Nata Pratama Hardjo Lugito

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